Medicinal Plant-derived Phytochemicals in Detoxification

  • Authors: Bjørklund G.1, Cruz-Martins N.2, Goh B.3, Mykhailenko O.4, Lysiuk R.5, Shanaida M.6, Lenchyk L.7, Upyr T.7, Rusu M.8, Pryshlyak A.9, Shanaida V.10, Chirumbolo S.11
  • Affiliations:
    1. Department of Research, Council for Nutritional and Environmental Medicine (CONEM)
    2. Facculty of Medicine, University of Porto
    3. Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy,, Monash University Malaysia
    4. Department of Pharmaceutical Chemistry, National University of Pharmacy
    5. Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University
    6. Department of Pharmacognosy and Medical Botany, Horbachevsky Ternopil National Medical University
    7. CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy
    8. Department of Pharmaceutical Technology and Biopharmaceutics,, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy
    9. Department of Human Anatomy, I. Horbachevsky Ternopil National Medical University
    10. Design of Machine Tools, Instruments and Machines Department, Ternopil Ivan Pului National Technical University
    11. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona
  • Issue: Vol 30, No 13 (2024)
  • Pages: 988-1015
  • Section: Immunology, Inflammation & Allergy
  • URL: https://ruspoj.com/1381-6128/article/view/645555
  • DOI: https://doi.org/10.2174/1381612829666230809094242
  • ID: 645555

Cite item

Full Text

Abstract

The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove toxins from the body. Worldwide, research is conducted to identify medicinal plant-derived molecules that, with few or no side effects, may protect the liver and other organs. This review provides updated information about the detoxification process, the traditional and modern use of the most effective medicinal plants, their active metabolites as detoxifying agents, and the mechanisms and pathways involved in the detoxification process. Among medicinal plants with substantial detoxifying properties, a major part belongs to the Asteraceae family (Silybum marianum, Cynara scolymus, Arctium lappa, Helichrysum species, Inula helenium, and Taraxacum officinale). The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the Silybum marianum seeds containing a mixture of flavonolignans. Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect. Overall, scientific data on medicinal plants used in phytotherapeutic practice worldwide provides an understanding and awareness of their efficacy in detoxification.

About the authors

Geir Bjørklund

Department of Research, Council for Nutritional and Environmental Medicine (CONEM)

Author for correspondence.
Email: info@benthamscience.net

Natália Cruz-Martins

Facculty of Medicine, University of Porto

Email: info@benthamscience.net

Bey Goh

Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy,, Monash University Malaysia

Email: info@benthamscience.net

Olha Mykhailenko

Department of Pharmaceutical Chemistry, National University of Pharmacy

Email: info@benthamscience.net

Roman Lysiuk

Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Mariia Shanaida

Department of Pharmacognosy and Medical Botany, Horbachevsky Ternopil National Medical University

Email: info@benthamscience.net

Larysa Lenchyk

CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy

Email: info@benthamscience.net

Taras Upyr

CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy

Email: info@benthamscience.net

Marius Rusu

Department of Pharmaceutical Technology and Biopharmaceutics,, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy

Email: info@benthamscience.net

Antonina Pryshlyak

Department of Human Anatomy, I. Horbachevsky Ternopil National Medical University

Email: info@benthamscience.net

Volodymyr Shanaida

Design of Machine Tools, Instruments and Machines Department, Ternopil Ivan Pului National Technical University

Email: info@benthamscience.net

Salvatore Chirumbolo

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona

Email: info@benthamscience.net

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