Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study


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Abstract

Object:The study aims to determine whether multimorbidity status is associated with cerebrospinal fluid (CSF) biomarkers for neurodegenerative disorders.

Methods:A total of 827 patients were enrolled from the Parkinson’s Progression Markers Initiative (PPMI) database, including 638 patients with early-stage Parkinson’s disease (PD) and 189 healthy controls (HCs). Multimorbidity status was evaluated based on the count of long-term conditions (LTCs) and the multimorbidity pattern. Using linear regression models, cross-sectional and longitudinal analyses were conducted to assess the associations of multimorbidity status with CSF biomarkers for neurodegenerative disorders, including α-synuclein (αSyn), amyloid-β42 (Aβ42), total tau (t-tau), phosphorylated tau (p-tau), glial fibrillary acidic protein (GFAP), and neurofilament light chain protein (NfL).

Results:At baseline, the CSF t-tau (p = 0.010), p-tau (p = 0.034), and NfL (p = 0.049) levels showed significant differences across the three categories of LTC counts. In the longitudinal analysis, the presence of LTCs was associated with lower Aβ42 (β < -0.001, p = 0.020), and higher t-tau (β = 0.007, p = 0.026), GFAP (β = 0.013, p = 0.022) and NfL (β = 0.020, p = 0.012); Participants with tumor/musculoskeletal/mental disorders showed higher CSF levels of t-tau (β = 0.016, p = 0.011) and p-tau (β = 0.032, p = 0.044) than those without multimorbidity.

Conclusion:Multimorbidity, especially severe multimorbidity and the pattern of mental/musculoskeletal/ tumor disorders, was associated with CSF biomarkers for neurodegenerative disorders in early-stage PD patients, suggesting that multimorbidity might play a crucial role in aggravating neuronal damage in neurodegenerative diseases.

About the authors

Ming-Zhan Zhang

School of Clinical Medicine, Shandong Second Medical University (formerly Weifang Medical University)

Email: info@benthamscience.net

Yan Sun

Department of Neurology, Qingdao Municipal Hospital, Qingdao University

Email: info@benthamscience.net

Yan-Ming Chen

Department of Neurology, Qingdao Municipal Hospital, Qingdao University

Email: info@benthamscience.net

Fan Guo

Department of Neurology, Qingdao Municipal Hospital, Qingdao University

Email: info@benthamscience.net

Pei-Yang Gao

Department of Neurology, Qingdao Municipal Hospital, Qingdao University

Email: info@benthamscience.net

Lan Tan

Department of Neurology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences

Email: info@benthamscience.net

Meng-Shan Tan

School of Clinical Medicine, Shandong Second Medical University (formerly Weifang Medical University)

Author for correspondence.
Email: info@benthamscience.net

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