A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series

Sarabpreet Singh; Arun Kumar Aggarwal; Rajendra Gudisa; Priyam Batra; Nitesh Kumar Rathi; Vibha Madan; Vipul Thakur; Harish Sharma; Rajesh Kumar; Siddhant Khare; Lipika Singhal; Rama Chaudhry; Neeraj Arora; Hardeep Singh; Jasjeet Kaur; Ashish Sharma; Ganesh Dakhale; Vijay Sharma; Vikas Gautam

doi:10.2174/0118715265260305231115112728

A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series

Authors: Singh S.¹, Aggarwal A.K.², Gudisa R.³, Batra P.⁴, Rathi N.K.⁵, Madan V.⁶, Thakur V.⁷, Sharma H.⁸, Kumar R.³, Khare S.⁷, Singhal L.⁹, Chaudhry R.⁴, Arora N.¹⁰, Singh H.¹¹, Kaur J.¹², Sharma A.¹, Dakhale G.¹³, Sharma V.¹⁴, Gautam V.³
Affiliations:
1. Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research
2. Radiation oncology, Aadhar Hospital
3. Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research
4. Department of Medical Microbiology, All India Institute of Medical Sciences
5. Department of Orthopaedics, Saveetha Institute of Medical and Technical Sciences
6. , Miri Piri Hospital
7. Department of General Surgery, Post Graduate Institute of Medical Education and Research
8. General Surgery, Aadhar Hospital
9. Department of Microbiology, Government Medical College and Hospital
10. Department of Microbiology, Civil Hospital
11. Department of General Surgery, Civil Hospital
12. , CMO, MT SAKET Hospital and Physiotherapy College
13. Department of Pharmacology, All India Institute of Medical Sciences (AIIMS)
14. Department of Orthopedics, Jai Prakash Narayan Apex Trauma Center (JPNATC), All India Institute of Medical Sciences (AIIMS)
Issue: Vol 24, No 4 (2024)
Section: Medicine
URL: https://ruspoj.com/1871-5265/article/view/645595
DOI: https://doi.org/10.2174/0118715265260305231115112728
ID: 645595

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Abstract

Introduction::Appropriate care and treatment of a wound is the need of the hour whether it is an infected or a non-infected wound. If wound healing is delayed for some reason, it leads to serious complications and further increases the hospital stay and cost of treatment. Herein, we describe a novel antimicrobial wound dressing formulation (VG111), with an objective to generate the preliminary data showing the distinct advantages in various types of wounds.

Method::This case series involved the treatment of acute cases of wounds or chronic wounds that did not respond well to conventional wound healing treatments with VG111 in patients with different etiologies. Thirteen cases of patients that included patients with diabetes, pressure ulcers, burns, trauma, and others treated with VG111 showed rapid wound healing in all the cases even obviating the need for a graft when complete skin regeneration occurred.

Result::This was illustrated by clearing of the wound infections, reduction/disappearance of the exudate, appearance of intense granulation, epithelialization, and anti-biofilm activity followed by complete wound closure. This VG111 precludes the need for systemic antimicrobial agents in localized infections and therefore, this single agent is an attempt to address the limitations and the drawbacks of the available products.

Conclusion::Despite patients belonging to the old age group and having comorbidities like diabetes, still VG111 showed effective rapid wound healing, and that too without any scar formation in hardto- heal, infected, and non-infected wounds.

Keywords

Non-healing ulcers, diabetic foot ulcer, MRSA, bedsore, potential treatment, non-healing ulcers.

References

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A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series

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Abstract

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References

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