Abstract
The article presents the data on the comparative study of efficiency of medications penetration and accumulation in the eye under the effect of a new method of infrasonic phonophoresis in retrobulbar and anterior non-injection way of radiopharmaceuticals administration with the following infrasonic impact on the eye during 10 minutes with frequency 4 Hz, power 173 dB in the live pressure mode of operation. The study was performed in 40 chinchilla rabbits (80 eyes). The obtained data is an evidence that under the impact of infrasound a significant accumulation of radiopharmaceuticals occur inside the eye in the anterior non-injection method of bringing medications to the eye (application of medication on cotton wool in conjunctival cavity of the eye), and in posterior way (retrobulbar injection) as well with their following distribution in the tissues of the eyeball. Infrasound improves pharmacokinetics in the eye contributing to the preservation of medicinal depot in the orbit and the eyeball, increasing the level of medication both in vascular and avascular structures of the eye.