Optical coherence tomography for evaluating the retina and choroid in children with intermediate uveitis

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Intermediate uveitis refers to the inflammation of the vitreous, ciliary body, and peripheral regions of the retina, and it is associated with rapid progression of macular edema and epiretinal membranes. Optical coherence tomography (OCT) examination of the retina and choroid in adult patients with intermediate uveitis demonstrates thickening in the central retina and absence of choroidal changes. Similar studies in children are lacking.

Aim: of our study was to analyze quantitative and qualitative changes in the retina and choroid in children with intermediate uveitis using OCT and to determine the possibility of using of these data for monitoring and evaluation of disease activity.

Material and methods: Twenty children with intermediate uveitis (39 eyes) aged 7–17 years were examined. In addition to standard ophthalmologic examination, all children were examined using OCT with the enhanced depth image module (EDI-OCT). The thicknesses of the retina and choroid were measured manually in the foveal zone and up to 3 mm in the nasal quadrant temporally, above, and below the fovea. Sixteen children (31 eyes) were examined for differences in disease activity and duration. The OCT examination results of the eyes of patients were compared with those of the healthy eyes (according to literature data).

Results: A significant increase in retinal thickness due to edema was observed across all measuring points in eyes with active inflammation as compared with eyes with inactive uveitis and healthy eyes. Macular edema was detected in 83% and 71% of the patients with active and moderate inflammation, respectively. Edemas were cystoid in 10% and diffuse in 90% of the patients. Analyses revealed a strong negative correlation between retinal thickness and uveitis duration. Choroid thickness varied only slightly among patients, with no significant differences across stages of inflammatory activity.

Conclusion: Our results confirm that macular edema has a higher rate of progression in children with active intermediate uveitis and that uveitis duration and central retinal thickness caused by macular edema resorption and by dystrophic processes are strongly negatively correlated. Uveitis inflammatory activity does not affect the thickness of the choroid in the central zone.

Full Text

Restricted Access

About the authors

Olga V. Novikova

Helmholtz National Medical Research Center of Eye Diseases

Author for correspondence.
Email: olganovv@mail.ru
ORCID iD: 0000-0002-8251-9775

MD

Russian Federation, Moscow, 105062

Lyudmila A. Katargina

Helmholtz National Medical Research Center of Eye Diseases

Email: info@igb.ru
ORCID iD: 0000-0002-4857-0374

MD, PhD, Professor

Russian Federation, Moscow, 105062

Ekaterina V. Denisova

Helmholtz National Medical Research Center of Eye Diseases

Email: deale_2006@inbox.ru
ORCID iD: 0000-0003-3735-6249

MD, Phd

Russian Federation, Moscow, 105062

References

  1. Sancho L, Kramer M, Koriat A, et al. Complications in intermediate uveitis: prevalence, time of onset, and effects on vision in short-term and long-term follow-up. Ocul. Immunol. Inflamm. 2019;27(3):447-55. doi: 10.1080/09273948.2017.1420203.
  2. Meshkova GI. Znachenie sovremennykh metodov vizualizatsii i otsenki zritel’nykh funktsii v diagnostike i lechenii perifericheskikh uveitov u detei i podrostkov. [dissertation] Moscow; 2008.
  3. Onal S, Tugal-Tutkun I, Neri P, Herbort C. Optical coherence tomography imaging in uveitis. Int. Ophthalmol. 2014; 34(2):401-35. doi: 10.1007/s10792-013-9822-7.
  4. Géhl Z, Kulcsár K, Kiss HJ, et al. Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis. BMC Ophthalmol. 2014;14:103. doi: 10.1186/1471-2415-14-103.
  5. Sugar EA, Jabs DA, Altaweel MM, et al. Identifying a clinically meaningfull thresholdfor change in uveitic macular edema evaluated by optical coherence tomography. Am. J. Ophthalmol. 2011;152(6):1044-52. doi: 10.1016/j.ajo.2011.05.028.
  6. Tran TH, de Smet MD, Bodaghi B, et al. Uveitic macular edema: correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography. Br. J. Ophthalmol. 2008;92(7):922–7. doi: 10.1136/bjo.2007.136846.
  7. Grajewski RS, Boelke AC, Adler W, et al. Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis. Eye (Lond). 2016;30(11):1415-23. doi: 10.1038/eye.2016.133.
  8. Kardes E, Sezgin Akçay BI, Unlu C, Ergin A. Choroidal thickness in eyes with fuchs uveitis syndrom. Ocul. Immunol. Inflamm. 2017;25(2):259-66. doi: 10.3109/09273948.2015.1115877.
  9. Hunter RS, Skondra D, Papaliodis G, Sobrin L. Role of OCT in the diagnosis and management of macular edema from uveitis. Semin. Ophthalmol. 2012;27(5-6):236-41. doi: 10.3109/08820538.2012.708813.
  10. Grajewski RS, Heindl LM. Macular thickening of uveitic eyes in the absence of macular oedema and epiretinal membranes. Acta Ophthalmol. 2017;95(1):e77-8. doi: 10.1111/aos.12920.
  11. Ishikawa S, Taguchi M, Muraoka T, et al. Changes in subfovealchoroidal thickness associated with uveitis activity in patients with Behcet’s disease. Br. J. Ophthalmol. 2014;98(11):1508-13. doi: 10.1136/bjophthalmol-2014-305333.
  12. Kim M, Kim H, Kwon HJ, et al. Choroidal thickness in Behcet’s uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Invest. Ophthalmol. Vis. Sci. 2013;54(9):6033-9. doi: 10.1167/iovs.13-12231.
  13. Mehta H, Sim DA, Keane PA, et al. Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis. Eye (Lond.). 2015;29(8):1060-8. doi: 10.1038/eye.2015.65.
  14. Güngör SG, Akkoyun I, Reyhan NH, et al. Choroidal thickness in ocular sarcoidosis during quiescent phase using enhanced depth imaging optical coherence tomography. Ocul. Immunol. Inflamm. 2014;22(4):287-93. doi: 10.3109/09273948.2014.920034.
  15. Katargina LA, Denisova EV, Novikova OV. The state of the choroid in children with anterior uveitis assessed by optical coherence tomography. Rossiiskii oftal’mologicheskii zhurnal. 2020;13(1):29-34. (in Russian) doi: 10.21516/2072-0076-2020-13-1-29-34.
  16. Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am. J. Ophthalmol. 2005;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057.
  17. Read SA, Collins MJ, Vincent SJ, Alonso-Caneiro D. Choroidal thickness in myopic and nonmyopic children assessed with enhanced depth imaging optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(12):7578-86. Doi: 10.1167/ iovs.13-12772.
  18. Turk A, Ceylan OM, Arici C, et al. Evaluation of the nerve fiber layer and macula in the eyes of healthy children using spectral-domain optical coherence tomography. Am. J. Ophthalmol. 2012;153(3):552-9. doi: 10.1016/j.ajo.2011.08.026.
  19. Bidaut-Garnier M, Schwartz C, Puyraveau M, et al. Choroidal thickness measurement in children using optical coherence tomography. Retina. 2014;34(4):768-74. doi: 10.1097/IAE.0b013e3182a487a4.

Supplementary files

Supplementary Files
Action
1. Fig. 1. Patient L. Macular OCT, active uveitis, diffuse macular edema. Note. Аrrows indicate extended due to edema hyporeflective space between outer limiting membrane and outer plexiform layer. Retina is “sponge-like” due to microcysts. Its thickness increased.

Download (119KB)
Indexing metadata
2. Fig. 2. Patient K. Macular OCT, active uveitis, cystoid macular edema. Note. Arrows indicate big cystoid spaces in foveal zone, which deform foveal curvature. Retinal thickness increased.

Download (105KB)
Indexing metadata
3. Fig. 3. Patient F. Macular OCT, active intermediate uveitis. Note. This figure demonstrates macular OCT of patient F. with active intermediate uveitis. Retinal layers are differentiated, foveal curvature is not changed, retinal thickness slightly increased. There are no cystoid spaces, but the reflectivity of retina decreased. It is probably the sign of intraretinal accumulation of fluid.

Download (131KB)
Indexing metadata
4. Fig. 4. Patient F. Macular OCT, inactive intermediate uveitis. Note. This figure demonstrates macular OCT of patient F. with inactive intermediate uveitis (medicine remission). Retinal layers are clearly differentiated, foveal curvature is not changed.

Download (93KB)
Indexing metadata
5. Fig. 5. Patient M. Macular OCT. Traction edema. Note. Arrow indicates epiretinal membrane, traction causes thickness increasing and deformation of retina. Foveal curvature is smoothed, cystoid spaces are absent, retinal thickness increased.

Download (94KB)
Indexing metadata
6. Fig. 6. Correlation between retinal thickness and disease duration (nasal).

Download (224KB)
Indexing metadata
7. Fig. 7. Correlation between retinal thickness and disease duration (temporal).

Download (223KB)
Indexing metadata
8. Fig. 8. Correlation between retinal thickness and disease duration (suprafoveal).

Download (211KB)
Indexing metadata
9. Fig. 9. Retinal thickness of the left eye of patient A., correlation with disease duration.

Download (133KB)
Indexing metadata

Copyright (c) 2020 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 28266 от 17.05.2007 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80630 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies