Bacterial corneal ulcers in pediatric patients: Clinical and laboratory diagnostics. Part I

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Bacterial corneal ulcer is the second most common complication of herpetic ulcer, but it is the most severe complication and has the highest progression rate. The main causative agents of bacterial corneal ulcers are Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Neisseria gonorrhoeae. The frequency of the detection of corneal ulcers caused by gram-negative Pseudomonas aeruginosa has increased, which is characterized by a lightning-fast course and a high frequency of complications and adverse outcomes. Gonococcal corneal ulcer caused by Neisseria gonorrhoeae is less common in pediatric patients than in adult patients, but it has the most aggressive disease course, which does not change with age. Bacterial corneal ulcers are one of the main causes of corneal blindness and can lead to endophthalmitis, corneal perforation, and eye loss within a short time. Clinical differential diagnostic signs allow us to assume, with a high degree of probability, the etiology at the first biomicroscopy and immediately begin etiotropic therapy, which is crucial for the outcomes of bacterial corneal ulcer. The standard laboratory examination of patients with bacterial corneal ulcer includes bacterioscopic and culture examinations of the contents of the conjunctival sac. This paper presents an up-to-date review of publications, clinical features, differential diagnostic criteria, laboratory diagnostic methods of bacterial corneal ulcers in pediatric patients

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Ludmila Kovaleva

Helmholtz National Medical Research Center of Eye Diseases

Author for correspondence.
ORCID iD: 0000-0001-6239-9553


Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Corneal ulcer caused by Streptococcus pneumonia with fluorescein staining.

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2. Fig. 2. Corneal ulcer caused by Pseudomonas aeruginosa.

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3. Fig. 3, а. Gonoblennorea in a 16-year-old patient.

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4. Fig. 3, b. Аcute conjunctivitis caused by Neisseria gonorrhoeae in a 16-year-old patient.

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