Correlation analysis of some functional and anatomical parameters of the visual analyzer in nystagmus and amblyopia of various origins

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Aim: To conduct a correlation analysis of the parameters of visual fixation, light sensitivity of the retina in the central region, and the thickness of the central region of the retina and choroid with the best corrected visual acuity (BCVA), refraction (SER), and axial length of the eye (AL) in nystagmus and amblyopia of various origins.

Material and methods: The study included 45 patients aged 5–44 years (mean 11.2±6.14 years). All patients were divided into six groups depending on the type of amblyopia and associated conditions (with nystagmus). The retinal photosensitivity and fixation parameters were studied using an MP-3 Nidek microperimeter (Japan). Chorioretinal parameters were studied using an RS-3000 Advance 2 spectral optical coherence tomograph (Nidek, Japan). The axial length of the eye was measured using a Galilei G6 Scheimpflug analyzer. Correlation analysis was performed using the linear Pearson correlation coefficient (r).

Results: In nystagmus, refractive and dysbinocular amblyopia, a strong direct correlation was found between the indicators of BCVA and the characteristics of fixation. In the groups associated with congenital myopia, relationships were found between BCVA, retinal thickness, and light sensitivity of the retina in the central region. There was no relationship between the subfoveal choroidal thickness and functional parameters of the eyes.

Conclusions: In nystagmus and amblyopia associated with strabismus and hyperopic refraction, the primary amblyogenic factor is a decrease in the density and amplitude of fixation. In relative amblyopia due to congenital myopia, the decrease in visual acuity correlates with the photosensitivity of the retina and does not correlate with fixation parameters, which indicates the partially organic nature of relative amblyopia. No relationship was found between the choroidae thikness and the degree of amblyopia, which does not cofine its participation in the pathogenesis of the disease.

Full Text

Restricted Access

About the authors

Regina R. Khubieva

Helmholtz National Medical Research Center of Eye Diseases

Author for correspondence.
Email: reginahubieva@mail.ru
ORCID iD: 0000-0002-8383-0127

MD, PhD student

Russian Federation, Moscow

Elena P. Tarutta

Helmholtz National Medical Research Center of Eye Diseases

Email: elenatarutta@mail.ru
ORCID iD: 0000-0002-8864-4518

Dr of Med. Sci, professor

Russian Federation, Moscow

Aleksander V. Apaev

Helmholtz National Medical Research Center of Eye Diseases

Email: doc229@mail.ru
ORCID iD: 0000-0001-7669-1256

research associate

Russian Federation, Moscow

Gajane A. Markosyan

Helmholtz National Medical Research Center of Eye Diseases

Email: dvdomdv@mail.ru
ORCID iD: 0000-0002-2841-6396

Dr of Med. Sci

Russian Federation, Moscow

References

  1. Wallace DK, Repka MX, Lee KA, et al. Amblyopia preferred practice pattern. Ophthalmology. 2018;125(1):105–142. doi: 10.1016/j.ophtha.2017.10.008
  2. Katargina LA, Mikhailova LA. The current stage of the ophtalmological care service in the Russian Federation (2012-2013). Rossiiskaya pediatricheskaya oftal’mologiya. 2015;10(1):5–10 (In Russ).
  3. Tarutta EP, Chernysheva SG, Gubkina GL, et al. A new way of diagnostic and treatment effectiveness evaluation of the optical nystagmus using microperimetry. Rossiiskaya pediatricheskaya oftal’mologiya. 2014;9(1):46–48 (In Russ).
  4. Khvatova NV, Slyshalova NN, Vakurina AE. Ambliopiya: zritel’nye funktsii, patogenez i printsipy lecheniya. In: Avetisov SE, Kashchenko TP, Shamshinova AM, editors. Zritel’nye funktsii i ikh korrektsiya u detei: Rukovodstvo dlya vrachei. Moscow: Meditsina; 2005. P. 202–220. (In Russ).
  5. Abadi RV, Scallan CJ. Waveform characteristics of manifest latent nystagmus. Invest Ophthalmol Vis Sci. 2000;41(12): 3805–3817.
  6. Carpineto P, Ciancaglini M, Nubile M, et al. Fixation patterns evaluation by means of MP-1 microperimeter in microstrabismic children treated for unilateral amblyopia. Eur J Ophthalmol. 2007;17(6):885–890. doi: 10.1177/112067210701700603
  7. Apaev AV, Tarutta EP. Comparative assessment of the parameters of visual fixation in amblyopia of different origin Vestnik oftal’mologii. 2020;136(2):26–31. (In Russ). doi: 10.17116/oftalma202013602126
  8. Pang Y, Goodfellow GW, Allison C, et al. A prospective study of macular thickness in amblyopic children with unilateral high myopia. Invest Ophthalmol Vis Sci. 2011;52(5):2444–2449. doi: 10.1167/iovs.10-5550
  9. Tarutta EP, Markosyan GA, Ryabina MV, et al. Morphometric and functional features of the macular region in patients with high congenital myopia. Vestnik oftal’mologii. 2012;128(1):3–8. (In Russ).
  10. Pang Y, Frantz KA, Block S, et al. Effect of amblyopia treatment on macular thickness in eyes with myopic anisometropic amblyopia. Invest Ophthalmol Vis Sci. 2015;56(4):2677–2683. doi: 10.1167/iovs.14-15532
  11. Shaikh AG, Otero-Millan J, Kumar P, Ghasia FF. Abnormal fixational eye movements in amblyopia. PLoS One. 2016;11(3):e0149953. doi: 10.1371/journal.pone.0149953
  12. Chen D, Otero-Millan J, Kumar P, et al. Visual search in amblyopia: abnormal fixational eye movements and suboptimal sampling strategies. Invest Ophthalmol Vis Sci. 2018;59(11):4506–4517. doi: 10.1167/iovs.18-24794
  13. Trabucco P, Mafrici M, Salomone M, et al. Microperimetric findings in children with amblyopia. Invest Ophthalmol Vis Sci. 2014;55(13):794.
  14. Park KA, Park DY, Oh SY. Analysis of spectral-domain optical coherence tomography measurements in amblyopia: a pilot study. Br J Ophthalmol. 2011;95(12):1700–1706. doi: 10.1136/bjo.2010.192765
  15. Szigeti A, Tátrai E, Szamosi A, et al. A morphological study of etinal changes in unilateral amblyopia using optical coherence tomography image segmentation. PLoS One. 2014;9(2):e88363. doi: 10.1371/journal.pone.0088363
  16. Boychuk IM, Yakhnitsa EI. Morphometric peculiarities of nerve fiber layer and optic disc in children with amblyopia and hypermetropic refraction. Oftal’mologicheskiy zhurnal. 2013;(6):17–22. (In Russ).
  17. Kasem MA, Badawi AE. Changes in macular parameters in different types of amblyopia: optical coherence tomography study. Clin Ophthalmol. 2017;11:1407–1416. doi: 10.2147/OPTH.S143223
  18. Kim YW, Kim SJ, Yu YS. Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients. Graefes Arch Clin Exp Ophthalmol. 2013;251(12):2811–2819. doi: 10.1007/s00417-013-2494-1
  19. Molina-Martín A, Piñero DP, Pérez-Cambrodí RJ. Fixation pattern analysis with microperimetry in nystagmus patients. Can J Ophthalmol. 2015;50(6):413–421. doi: 10.1016/j.jcjo.2015.07.012
  20. Kavitha V, Heralgi MM, Harishkumar PD, et al. Analysis of macular, foveal, and retinal nerve fiber layer thickness in children with unilateral anisometropic amblyopia and their changes following occlusion therapy. Indian J Ophthalmol. 2019;67(7):1016–1022. doi: 10.4103/ijo.IJO_1438_18
  21. Nishi T, Ueda T, Hasegawa T, et al. Choroidal thickness in children with hyperopic anisometropic amblyopia. Br J Ophthalmol. 2014;98(2):228–232. doi: 10.1136/bjophthalmol-2013-303938
  22. Niyaz L, Yucel OE, Ariturk N, Terzi O. Choroidal thick-ness in strabismus and amblyopia cases. Strabismus. 2017;25(2):56–59. doi: 10.1080/09273972.2017.1318152

Copyright (c) 2021 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies