Clinical pathology and diagnostics of nystagmus

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Abstract

Optical nystagmus is an involuntary oscillatory movement. Nystagmus can occur as an isolated nosology and lead to decreased visual functions in combination with other pathologies. A decreased visual function, including visual acuity, is observed in many patients with optic nystagmus. Patients with optical nystagmus were noted by ophthalmologists with a significant difference in the acuity of monocular and binocular vision, which is much higher in the second case. As a rule, a difference is observed in visual acuity in the straight and forced position of the head. Frequently, nystagmus is combined with refractive errors. Some authors consider astigmatism the most common form of ametropia in nystagmus, and nystagmus itself, a predisposing factor for the presence of astigmatism. An important task in diagnostics is the quantitative eye movement assessments since the tactics of treatment and the prognosis of the course of the disease depend on this. One of the problems in the examination of patients with nystagmus is the assessment of the fundal condition. Modern optical coherence tomographs are helpful in the objective diagnostics of retinal structures of the posterior pole of the eye, as well as improved software, such as the “Eye Tracking” system, and an increased scanning speed allowed reliable studies even with spontaneous oscillatory eye movements and a significantly decreased visual acuity. With nystagmic relative amblyopia, both photosensitivity and fixation were violated, which may indicate the presence of organic changes in the central parts of the retina and a primary fixation violation.

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About the authors

Aleksander V. Apaev

Helmholtz National Medical Research Center of Eye Diseases

Author for correspondence.
Email: doc229@mail.ru
ORCID iD: 0000-0001-7669-1256

researcher

Russian Federation, 14/19, Sadovaya Chernogryazskaya Street, Moscow, 105062

References

  1. Avetisov ES, Shapovalov SL, Anikina EB. K voprosu o retinal’noi ostrote zreniya u bol’nykh nistagmom. In: Tezizy dokladov VII Respublikanskoi konferentsii Litovskoi SSR «Aktual’nye voprosy oftal’mologii». Kaunas; 1980. P:88–89. (In Russ).
  2. Archulene VY, Chyaponene R. Nekotorye klinicheskie aspekty vrozhdennogo nistagma. In: Tezizy dokladov VII Respublikanskoi konferentsii Litovskoi SSR «Aktual’nye voprosy oftal’mologii». Kaunas; 1980. P:92–93. (In Russ).
  3. Senyakina A.S. Kliniko-diagnosticheskoe znachenie nistagma i osobennosti obsledovaniya bol’nykh opticheskim nistagmom. Journal of ophthalmology. 1970;(2):85–90. (In Russ).
  4. Haase W, Schulz CP. A simple method of assessing monocular visual acuity in nystagmus. Ophthalmologica. 1982;185(2):90–93. doi: 10.1159/000309229
  5. Senyakina AS. Klinicheskie osobennosti i rezul’taty khirurgicheskogo i pleopticheskogo lecheniya bol’nykh s nistagmom [dissertation]. Odessa; 1970. (In Russ).
  6. Proskurina OV. Akkomodatsionnaya sposobnost’ glaz u bol’nykh opticheskim nistagmom i vozmozhnosti ee vosstanovleniya [dissertation]. Moscow; 1994. (In Russ).
  7. Ukwade MT, Bedell HE. Variation of congenital nystagmus with viewing distance. Optom Vis Sci. 1992;69(12):976–985. doi: 10.1097/00006324-199212000-00012
  8. Hanson KS, Bedell HE, White JM, Ukwade MT. Distance and near visual acuity in infantile nystagmus. Optom Vis Sci. 2006;83(11):823–829. doi: 10.1097/01.opx.0000238650.33150.73
  9. Avetisov ES, Smol’yaninova IL, Shapovalov SL. Novye vozmozhnosti uluchsheniya zritel’nykh funktsii pri nistagme. The Russian Annals Of Ophthalmology. 1979;95(3):26–32. (In Russ).
  10. Dell’Osso LF. Nystagmus and other opto-motor oscillations. In: Neuroophthalmology. 1983. P:172–210.
  11. Senyakina AC. Kharakter optokineticheskogo nistagma pri narusheniyakh refleksa monokulyarnoi zritel’noi fiksatsii Oftal’mologicheskij zhurnal. 1978;33(1):45–50. (In Russ).
  12. Cebon L, West RH. A syndrome involving congenital cataracts of unusual morphology, microcornea, abnormal irides, nystagmus and congenital glaucoma, inherited as an autosomal dominant trait. Aust J Ophthalmol. 1982;10(4):237–242. doi: 10.1111/j.1442-9071.1982.tb01623.x
  13. Coll J. Nystagmographie et pathologie cervicale. Rev Otoneuroophtalmol. 1982;(5):417–445.
  14. Douche C, Zenatti C. Results of early treatment of congenital strabismus. J Fr Ophtalmol. 1992;15(10):525–528.
  15. Boniver R. Systematization des nystagmus de position. J Fr Otorhinolaryngol. 1982;(10):747–752.
  16. Ciuffreda KJ, Rumpf D. Contrast and accommodation in amblyopia. Vision Res. 1985;25(10):1445–1457. doi: 10.1016/0042-6989(85)90223-8
  17. Fresina M, Benedetti C, Marinelli F, et al. Astigmatism in patients with idiopathic congenital nystagmus. Graefes Arch Clin Exp Ophthalmol. 2013;251(6):1635–1639. doi: 10.1007/s00417-013-2290-y
  18. Healey N, McClelland JF, Saunders KJ, Jackson AJ. Longitudinal study of spherical refractive error in infantile nystagmus syndrome. Ophthalmic Physiol Opt. 2014;34(3):369–375. doi: 10.1111/opo.12117
  19. Smol’yaninova IL. Sostoyanie akkomodatsii pri nistagme i vozmozhnosti ee uluchsheniya i kompensatsii. Oftal’mologicheskij zhurnal. 1998;(2):89–93. (In Russ).
  20. Burke JP, West NF, Strachan IM. Congenital nystagmus, anisomyopia, and hemimegalencephaly in the Klippel-Trenaunay-Weber syndrome. J Pediatr Ophthalmol Strabismus. 1991;28(1):41–44.
  21. de Vries J. Anisometropia in children: analysis of a hospital population. Br J Ophthalmol. 1985;69(7):504–507. doi: 10.1136/bjo.69.7.504
  22. Guo S. Visual acuity determinants in infantile nystagmus. Invest Ophthalmol Vis Sci. 1990;(31):83–84.
  23. Arden GB, Constable PA. The electro-oculogram. Prog Retin Eye Res. 2006;25(2):207–248. doi: 10.1016/j.preteyeres.2005.11.001
  24. Lambert SR, Taylor D, Kriss A. The infant with nystagmus, normal appearing fundi, but an abnormal ERG. Surv Ophthalmol. 1989;34(3):173–186. doi: 10.1016/0039-6257(89)90101-x
  25. Harris C. Infantile nystagmus syndrome: what can FMRI tell us? J Pediatr Ophthalmol Strabismus. 2012;49(3):189. doi: 10.3928/01913913-20120403-02
  26. Levo H, Aalto H, Petteri Hirvonen T. Nystagmus measured with video-oculography: methodological aspects and normative data. ORL J Otorhinolaryngol Relat Spec. 2004;66(3):101–104. doi: 10.1159/000079327
  27. Kumar A, Krol G. Binocular infrared oculography. Laryngoscope. 1992;102(4):367–378. doi: 10.1288/00005537-199204000-00002
  28. Mezawa M, Yamada T, Ukai K, Ishikawa S. Congenital nystagmus waveform and foveation observed using infrared television fundus camera. Nippon Ganka Gakkai Zasshi. 1987;91(2):270–276.
  29. Reccia R, Roberti G, Russo P. Spectral analysis of pendular waveforms in congenital nystagmus. Ophthalmic Res. 1989;21(2):83–92. doi: 10.1159/000266783
  30. Boricean ID, Barar A. Understanding ocular torticollis in children. Oftalmologia. 2011;55(1):10–26.
  31. Dell’Osso LF, Daroff RB. Abnormal head position and head motion associated with nystagmus. In: Adaptive Processes in Visual and Oculomotor Systems. Pergamon Press; 1986. P:473–478
  32. Abel LA. Infantile nystagmus: current concepts in diagnosis and management. Clin Exp Optom. 2006;89(2):57–65. doi: 10.1111/j.1444-0938.2006.00024.x
  33. Dahan A, Spielman A. Nystagmus aves double torticolis. Bull Soc Ophthalmol. 1988;(2):287–290.
  34. Abadi RV, Whittle J. The nature of head postures in congenital nystagmus. Arch Ophthalmol. 1991;109(2):216–220. doi: 10.1001/archopht.1991.01080020062044
  35. Abadi RV, Bjerre A. Motor and sensory characteristics of infantile nystagmus. Br J Ophthalmol. 2002;86(10):1152–1160. doi: 10.1136/bjo.86.10.1152
  36. Spielmann A. Clinical rationale for manifest congenital nystagmus surgery. J AAPOS. 2000;4(2):67–74. doi: 10.1067/mpa.2000.103433
  37. Hertle RW, Maldanado VK, Maybodi M, Yang D. Clinical and ocular motor analysis of the infantile nystagmus syndrome in the first 6 months of life. Br J Ophthalmol. 2002;86(6):670–675. doi: 10.1136/bjo.86.6.670
  38. Holmstrom G, Eriksson U, Hellgren K, Larsson E. Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia. Acta Ophthalmol. 2010;88(4):439–442. doi: 10.1111/j.1755-3768.2009.01533.x
  39. Lee H, Sheth V, Bibi M, et al. Potential of handheld optical coherence tomography to determine cause of infantile nystagmus in children by using foveal morphology. Ophthalmology. 2013;120(12):2714–2724. doi: 10.1016/j.ophtha.2013.07.018
  40. Seo JH, Yu YS, Kim JH, et al. Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology. 2007;114(8):1547–1551. doi: 10.1016/j.ophtha.2006.10.054
  41. Healey N, McLoone E, Mahon G, et al. Investigating the relationship between foveal morphology and refractive error in a population with infantile nystagmus syndrome. Invest Ophthalmol Vis Sci. 2013;54(4):2934–2939. doi: 10.1167/iovs.12–11537
  42. Lee H, Sheth V, Bibi M, et al. Potential of handheld optical coherence tomography to determine cause of infantile nystagmus in children by using foveal morphology. Ophthalmology. 2013;120(12):2714–2724. doi: 10.1016/j.ophtha.2013.07.018
  43. Thomas MG, Kumar A, Mohammad S, et al. Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity? Ophthalmology. 2011;118(8):1653–1660. doi: 10.1016/j.ophtha.2011.01.028
  44. Rufai SR, Thomas MG, Purohit R, et al. Can Structural Grading of Foveal Hypoplasia Predict Future Vision in Infantile Nystagmus?: A Longitudinal Study. Ophthalmology. 2020;127(4):492–500. doi: 10.1016/j.ophtha.2019.10.037
  45. Wang FB. Nystagmus associated with macular dysplasia. Strabismus. 2020;28(1):17–19. doi: 10.1080/09273972.2019.1668028
  46. Longhin E, Convento E, Pilotto E, et al. Static and dynamic retinal fixation stability in microperimetry. Can J Ophthalmol. 2013;48(5):375–380. doi: 10.1016/j.jcjo.2013.05.021
  47. Molina A, Perez-Cambrodi RJ, Ruiz-Fortes P, et al. Utility of microperimetry in nystagmus: a case report. Can J Ophthalmol. 2013;48(5):e103–105. doi: 10.1016/j.jcjo.2013.07.017
  48. Molina-Martin A, Pinero DP, Perez-Cambrodi RJ. Fixation pattern analysis with microperimetry in nystagmus patients. Can J Ophthalmol. 2015;50(6):413–421. doi: 10.1016/j.jcjo.2015.07.012
  49. Tarutta EP, Khubieva RR, Apaev AV, et al. Correlations between visual fixation parameters, photosensitivity of the retina and visual acuity in various types of amblyopia. Vestn Oftalmol. 2021;137(3):32–38. (In Russ). doi: 10.17116/oftalma202113703132
  50. Shamshinova AM. Funktsional’nye metody issledovaniya v oftal’mologii. Moscow: Meditsina; 2001. (In Russ).
  51. Stang HJ. Developmental disabilities associated with congenital nystagmus. J Dev Behav Pediatr. 1991;12(5):322–323.
  52. Hertle RW, Reese M. Clinical contrast sensitivity testing in patients with infantile nystagmus syndrome compared with age-matched controls. Am J Ophthalmol. 2007;143(6):1063–1065. doi: 10.1016/j.ajo.2007.02.028
  53. Abadi RV, King-Smith PE. Congenital nystagmus modifies orientational detection. Vision Res. 1979;19(12):1409–1411. doi: 10.1016/0042-6989(79)90215-3
  54. Dickinson CM, Bedell HE. The elucidation and use of the effect of near fixation in congenital nystagmus. Ophthalmic Physiol Opt. 1986;(6):303–311.
  55. Weiss AH, Biersdorf WR. Visual sensory disorders in congenital nystagmus. Ophthalmology. 1989;96(4):517–523. doi: 10.1016/s0161-6420(89)32864-8
  56. Abadi RV, Pascal E. Incremental light detection thresholds across the central visual field of human albinos. Invest Ophthalmol Vis Sci. 1993;34(5):1683–1690.
  57. Bedell HE. Variability of foveation congenital nystagmus. Clin Vis Sci. 1989;(4):247–252.
  58. Bedell HE, Currie DC. Extraretinal signals for congenital nystagmus. Invest Ophthalmol Vis Sci. 1993;34(7):2325–2332.
  59. Good PA, Searle AE, Campbell S, Crews SJ. Value of the ERG in congenital nystagmus. Br J Ophthalmol. 1989;73(7):512–515. doi: 10.1136/bjo.73.7.512
  60. Zhang W, Zhao K. Multifocal electroretinography in central serous chorio-retinopathy and assessment of the reproducibility of the multifocal electroretinography. Doc Ophthalmol. 2003;106(2):209–213. doi: 10.1023/a:1022592310917
  61. Shamshinova AM. Rol’ biopotentsialov setchatki v izuchenii mekhanizmov vozniknoveniya nistagma. The Russian Annals of Ophthalmology.1991;(6):46–51. (In Russ).
  62. Abadi RV, Worfolk R. Retinal slip velocities in congenital nystagmus. Vision Res. 1989;29(2):195–205. doi: 10.1016/0042-6989(89)90124-7
  63. Abadi RV, Whittle J. The nature of head postures in congenital nystagmus. Arch Ophthalmol. 1991;109(2):216–220. doi: 10.1001/archopht.1991.01080020062044
  64. Holder GE, Robson AG, Hogg CR, et al. Pattern ERG: clinical overview, and some observations on associated fundus autofluorescence imaging in inherited maculopathy. Doc Ophthalmol. 2003;106(1):17–23. doi: 10.1023/a:1022471623467
  65. Marmor MF, Hood DC, Keating D, et al. Guidelines for basic multifocal electroretinography (mfERG). Doc Ophthalmol. 2003;106(2):105–115. doi: 10.1023/a:1022591317907
  66. Daktaravichene EY, Archulene YV. Klinicheskoe izuchenie i vozmozhnosti kompleksnogo (konservativnogo i khirurgicheskogo) lecheniya pri vrozhdennom nistagme. Journal Of Ophthalmology.1989;44(3):150–154. (In Russ).
  67. Shamshinova AM. Hereditary and congenital diseases of the retina and optic nerve. Moscow: Medicina; 2001. (In Russ).
  68. Kelly JP, Phillips JO, Weiss AH. The relationship of nystagmus waveform on the VEP response in infantile nystagmus syndrome: a small case series. Doc Ophthalmol. 2017;134(1):37–44. doi: 10.1007/s10633-016-9568-4

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