Toxicokinetics of aluminum in rats

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Abstract

Introduction. Aluminum is one of the most common elements in nature that is potentially toxic to humans. Aluminum compounds are widely used in the aviation and food industries, metallurgy, electrical engineering, and medicine. Aluminum is capable of accumulating in the human body, which creates a risk for the development of severe diseases.

Material and methods. Acute intoxication of aluminum hydroxide was simulated on white outbred rats weighing 170-220 g, divided into 8 groups (intact and 7 experimental). By the atomic absorption method, the concentrations of aluminum, calcium, magnesium, and iron in the organs of laboratory animals (kidneys, liver, blood, and brain) were determined 1, 2, 4, 6, 24, 48, and 96 hours after intoxication.

Results. The accumulation of aluminum was observed to a greater extent in the liver, kidneys, blood, to a lesser extent in the brain. Aluminum affects the homeostasis of essential elements, for example, in the experiment, a decrease in the content of calcium and magnesium in the organs of laboratory animals is observed. The seed level does not have a strong effect on the level of iron. At the end of the experiment, the concentration of aluminum in the liver, blood, and brain of rats remains higher than in the control group.

Conclusion. Aluminum is capable of accumulating in vital organs and affecting the homeostasis of the essential elements of the body. The circulation of aluminum in the biological media of a living organism, like many processes, is undulating, and it can accumulate and diffuse for a long time in various organs of experimental animals.

About the authors

Elza N. Usmanova

Ufa Research Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: elza90@inbox.ru
ORCID iD: 0000-0002-5455-6472

MD, junior researcher of the Chemical analysis Department of Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russia Federation.

e-mail: elza90@inbox.ru

Russian Federation

Anna S. Fazlyeva

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0037-6791
Russian Federation

Denis O. Karimov

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0039-6757
Russian Federation

Munira M. Ziatdinova

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1848-7959
Russian Federation

Rustem A. Daukaev

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0421-4802
Russian Federation

Nadezhda Yu. Khusnutdinova

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0001-5596-8180
Russian Federation

Mihail V. Kurilov

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2818-1558
Russian Federation

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Copyright (c) 2024 Usmanova E.N., Fazlyeva A.S., Karimov D.O., Ziatdinova M.M., Daukaev R.A., Khusnutdinova N.Y., Kurilov M.V.


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