Evaluation of the efficiency programs of correction of fatial exchange disorders in children consuming drinking water with non-format level organic chlorine compounds (chloroform)

Introduction. We performed a sanitary-hygienic analysis and assessed quality of the environment on Perm region territories the population of which permanently consumed water with increased contents of chlorinated organic compounds (COCs) from centralized drinking water supply systems.

Material and methods. We accomplished a profound clinical and laboratory examination of 120 children (52 boys and 68 girls) aged of 4-15 years who permanently lived on territories where drinking water quality was unsatisfactory as per sanitary-chemical parameters; the examined children had disorders in their lipid metabolism, deviations in their physical development (excessive body mass E67.8, obesity E66.0), and increased chloroform contents in their blood.

The results of the study. Under the oral exposure to COCs children who had increased chloroform concentrations in their blood suffered from lipid metabolism disorders 2.4 times (16%) more frequently than children from the reference group (6.5%, р=0.02-0.15). We analyzed an efficiency of technologies applied for correction of lipid metabolism disorders associated with exposure to COCs; the analysis proved a high (from 1.6 to 3.2 times) clinical efficiency of medications with membrane-stabilizing, hepatoprotective, antioxidant, and nootropic effects, when they were applied together with physiotherapy techniques (transcranial magnetotherapy, inductothermy), and therapeutic physical training.

The discussion of the results. An application of the developed correction technology resulted in a significant decrease in intensity of the previously detected cause-and-effect relation (ОR = 2.74; CI = 1.16-7.14; р < 0.05) between lipid metabolism disorders and consumption of drinking water with increased chloroform contents (ОR=1.07; CI=0.35-3.23; р <0.05). The obtained data are consistent with previous studies and the opinion of a number of authors that the use of pathogenetically substantiated approaches in the correction of environmentally caused health disorders allows achieving the highest possible efficiency of medical and preventive measures.

Conclusion. We revealed a newly developed technology to allow achieving a 2.4-2.5-fold decrease in the morbidity rate of the obesity (E66.0) and excessive body mass (E67.8) (р=0.042-0.047) as compared to conventional approaches.