Indices of peculiarities of immune regulation detected in children exposed to environmental contamination with metals

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Abstract

Introduction. The technogenic development of the habitat determines the need of study of the negative impact of environmental factors on public health.

The aim of the work is to study the peculiarities of changes of indices of immune regulation, specific and non-specific sensitization in the children’s population, living in conditions of air pollution with metals.

Material and methods. A survey of the children population, living in the exposure zone of the studied risk factors was conducted. Mass spectrometry was used to determine the concentrations of chemical elements in biological media. Phagocytic activity was determined using sheep erythrocytes, serum immunoglobulin concentrations - using radial immunodiffusion, total IgE and cytokine levels - using enzyme immunoassay, specific IgG and IgE antibodies to metals - using allergen sorbent testing method. Statistical analysis was performed using Statistica 6.0.

Results. In the observation group №. 1 the level of blood contamination with aluminum and chromium compounds when compared to the indices of the comparison group was higher, as well as there was a gain in aluminum, manganese, nickel, chromium in the blood level, compared with the values of the observation group №. 2. In the observation group № 1, the relative phagocytosis and phagocytic number were lower in relation to the norm, to the comparison group and the observation group № 2. Specific antibodies to metals exceeded the reference levels in the observation groups № 1 and № 2. The production of interleukin-1beta in the observation groups № 1 and № 2 exceeded the comparison indices; high levels of interleukin-8 and interferon-gamma were noted. A violation of cellular immunity in the observation group № 1 was established. In observation group № 2, changes in immune reactivity were expressed in a less degree, which was characterized by reduced absolute values of metals sensitivity indices.

Conclusion. Excessive blood contamination with aluminum and chromium compounds, a decrease in phagocytic activity, an increase in specific sensitization by the criterion for the content of specific antibodies to metals, as well as an imbalance of cytokine immune mediators, were shown.

About the authors

K. G. Starkova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0002-5162-9234
Russian Federation

Oleg V. Dolgikh

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; Perm State University; Perm National Research Polytechnic University

Email: oleg@fcrisk.ru
ORCID iD: 0000-0003-4860-3145

MD, Ph.D., DSci., head of the department of immunobiological diagnostic methods of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation.

e-mail: oleg@fcrisk.ru

Russian Federation

D. A. Eisfeld

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0442-9010
Russian Federation

I. N. Alikina

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2057-9828
Russian Federation

N. A. Nikonoshina

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7271-9477
Russian Federation

Yu. A. Chelakova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9421-6536
Russian Federation

References

  1. Zaitseva N.V., Lanin D.V., Chereshnev V.A. [Immunnaya i neiroendokrinnaya regulyatsiya v usloviyakh vozdeistviya khimicheskikh faktorov razlichnogo geneza]. Perm’: Izdatel’stvo Perm. nats. issled. politekhn. universiteta; 2016: 236. (in Russian)
  2. Dolgikh О.V., Krivtsov А.V., Starkova К.G., Luchnikova V.А., Bubnova О.А., Dianova D.G., Bezruchenko N.V., Vdovina N.A. Neurotransmitter system of immune regulation as a marker of immunological disorders in pupils in the conditions of increased entry of strontium with drinking water. Analiz riska zdorov’yu. 2015; 3: 61–7. doi: 10.21668/health.risk/2015.3.09.eng (in Russian).
  3. Savilov E.D., Anganova E.V., Ilina I.V., Stepanenko L.A. Technogenic environmental pollution and the public health: analysis and prognosis. Gigiena i sanitariya. 2016; 95(6): 507–12 (in Russian).
  4. Dolgikh O.V. Zaitseva N.V., Krivtsov A.V., Gorshkova K.G., Lanin D.V., Bubnova O.A. Immune system and its genetic associations in children with combined external influence. Vestnik Kazakhskogo Natsional’nogo meditsinskogo universiteta. 2014; 3(1): 60–3 (in Russian).
  5. Zaitseva N.V., Ustinova O.YU., Aminova A.I. Hygienic aspects of violation of children’s health under the influence of chemical environmental factors [Gigienicheskie aspekty narusheniya zdorov’ya detey pri vozdeystvii khimicheskikh faktorov sredy obitaniya]. Perm’: Knizhnyy format; 2011: 489. (in Russian).
  6. Lanin D.V., Zaitseva N.V., Zemlyanova M.A., Dolgih O.V., Dianova D.G. Characteristics of regulatory system in children exposed to the environmental chemical factors. Gigiena i sanitariya. 2014; 93(2): 23–6. (in Russian).
  7. Smagulov N.K. Azhimetova G.N. Role of factors of environment in formation of health level of the population. Mezhdunarodnyi zhurnal eksperimental’nogo obrazovaniya. 2013; 11-1: 57–60 (in Russian).
  8. MacGillivray D.M., Kollmann T.R. The role of environmental factors in modulating immune responses in early life. Front. Immunol., 2014; 5: 434.
  9. Zaitseva N.V., May I.V., Kleyn S.V. On the determination and proof of damage to human health due to an unacceptable health risk caused by environmental factors. Analiz riska zdorov’yu. 2013; 2: 14–27. (in Russian)
  10. Dikopolskaya N.B., Sitdikov F.G. Adaptive reactions of children of the school age in polluted environment. Filologiya i kul’tura. 2010; 4(22): 77–81. (in Russian)
  11. Meshkov N.A. Assesment of adaptive response on envinromental risk factors: methodological factors. Gigiena i sanitariya. 2012; 5: 87–91. (in Russian)
  12. Starkova K.G., Alikina I.N., Gusel’nikov M.A., Nikonoshina N.A., Krivtsov A.V., Perminova I.V. et al. Changes of immune regulatory markers in children’s population under conditions of industrial pollution by metals. Rossiiskii immunologicheskii zhurnal. 2017; 11(3): 512–4. (in Russian).
  13. Dolgikh O.V., Zaitseva N.V., Luzhetsky K.P., Andreeva E.E. Characteristics of immune and genetic disadaptation in children under hapten excessive load. Rossiyskiy immunologicheskiy zhurnal. 2014; 8(17): 299–302. (in Russian)
  14. Dolgikh O., Zaitseva N., Dianova D., Krivtsov A. Molecular markers of apoptosis in industrial workers. In vivo: international Journal of Experimental and Clinical Pathophysiology and Drub Research. 2011; 25(3): 523–4.
  15. Dolgikh O.V., Krivtsov A.V., Kharakhorina R.A. Immune and DNA markers of exposure to environmental factors. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki. 2012; 4: 240–1 (in Russian)
  16. Boverhof D.R., Ladics G., Luebke B. et al. Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary. Regulatory Toxicology and Pharmacology 2014; 68 (1): 96–107.
  17. Duramad P., Holland N.T. Biomarkers of immunotoxicity for environmental and public health research. Int. J. Environ. Res. Public Health 2011; 8 (5): 1388–401.
  18. Alekseev L.P., Khaitov R.M. Regulatory role of immune system in organism. Rossiyskiy fiziologicheskiy zhurnal imeni I.M. Sechenova. 2010; 96(8): 787–805. (in Russian)
  19. Zasorin B.V., Kurmangaliev O.M., Ermukhanova L.S. Features of the immune status in the population of urban areas with a high content of heavy metals. Gigiena i sanitariya. 2012; 3: 17–9. (in Russian)
  20. Lehmann I., Sack U., Lehmann J. Metal ions affecting the immune system. Met. Ions Life Sci. 2011; 8: 157–85.
  21. McKee A.S., Fontenot A.P. Interplay of innate and adaptive immunity in metal-induced hypersensitivity. Curr. Opin. Immunol. 2016; 42: 25–30.
  22. Ohsawa M. Heavy metal-induced immunotoxicity and its mechanisms. Yakugaku Zasshi. 2009; 129 (3): 305–19.
  23. Rukavishnikov V.S., Efimova N.V. About the problem of environmental-caused health disorders. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya RAMN. 2012; 2(2): 95–8. (in Russian).
  24. Dautov F.F. Impact of ambient air pollution on allergic morbidity in children in a large industrial town. Gigiena i sanitariya. 2007; 2: 10–2. (in Russian).
  25. Onishchenko G.G., Zaitseva N.V., Zemlyanova M.A. Hygienic indication of the health consequences of external exposure of chemical elements [Gigienicheskaya indikatsiya posledstviy dlya zdorov’ya pri vneshnesredovoy ekspozitsii khimicheskikh elementov]. Perm’: Knizhnyy format; 2011: 489. (in Russian)
  26. Rakhmanin Yu.A., Mikhaylova R.I. Environment and health: priorities for preventive medicine. Gigiena i sanitariya. 2014; 5: 5–10. (in Russian).
  27. Revich B.A. Ecological priorities and health: socially vulnerable territories and risk groups. Ekologiya cheloveka. 2010; 7: 3–9 (in Russian).
  28. Kazantseva L.K., Tagaeva T.O. Environmental and health situation in Russian regions. Sovremennye issledovaniya sotsial’nykh problem 2011 8(4): 46–59 (in Russian).
  29. Belousova N.A. Shibkov A.A., Bayguzhin P.A. A medical examination of children and adolescents living in industrial cities. Vestnik Rossiyskogo universiteta druzhby narodov. Seriya: Ekologiya i bezopasnost’ zhiznedeyatel’nosti». 2013; 2: 38–43 (in Russian).
  30. Shibkova D.Z., Semenova M.V., Shibkov A.A. The integrated development features of children living in zones of ecological trouble. Vestnik Rossiyskogo universiteta druzhby narodov. Seriya: Ekologiya i bezopasnost’ zhiznedeyatel’nosti. 2014; 4: 53–62 (in Russian)

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Copyright (c) 2024 Starkova K.G., Dolgikh O.V., Eisfeld D.A., Alikina I.N., Nikonoshina N.A., Chelakova Y.A.


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