Results of corneal collagen crosslinking in children and adolescents with keratoconus I-III stage

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Aim. To estimate effectiveness and results of Corneal collagen crosslinking keratoconus treatment in children in a year after the treatment.

Material and methods. 15 patients (21 eyes ) aged 11-18 with keratoconus I-III st. were studied before the CXL and a year after the surgery. We compared their data of standart ophthalmological and deep keratotopographic investigations, included best corrected and uncorrected VA, keratometry, pachimetry, refraction, corneal OCT e.t.c.

Results. No intra- or postoperative complications were observed. In a year after CXL we found statistically significant improve in VA (uncorrected and best corrected) in children, stability and improvement of corneal characteristics as decrease in SE of myopia and stabilization of all topographic indices.

Conclusion. CXL is a safe and effective method for the stabilization of progressive keratoconus in children. It halted disease and improves corneal topography and visual functions in children and adolescents. But we should manage such patients very carefully as keratoconus in children tends to be more aggressive and unpredictable in its progression.

Full Text

Restricted Access

About the authors

Kristina K. Shefer

The S. Fyodorov Eye Microsurgery Federal State Institution; North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: kristinashefer@yahoo.com
ORCID iD: 0000-0003-0568-6593

PhD, MD

Russian Federation, Saint Petersburg; Saint Petersburg

Dilara R. Mirsaitova

The S. Fyodorov Eye Microsurgery Federal State Institution

Email: kristinashefer@yahoo.com
ORCID iD: 0000-0002-8825-312X

MD

Russian Federation, Saint Petersburg

Aleksey V. Titov

The S. Fyodorov Eye Microsurgery Federal State Institution

Email: kristinashefer@yahoo.com
ORCID iD: 0000-0001-6847-4737

MD

Russian Federation, Saint Petersburg

References

  1. Abugova TD. Contact lences and keratoplasty for patients with keratoconus. Glaz. 1999; (1). (In Russ.)
  2. Abugova TD. Early diagnostic and rehabilitation of patients with keratoconus by contact correction of vision [dissertation abstract]. Мoscow; 1986. 17 p. (In Russ.)
  3. Avetisov SE, Pershin KB, Pashinova NF. Diagnostics of keratoconus. Glaz. 1999;(1):12-15. (In Russ.)
  4. Gorskova EN, Sevastyanov EN. The visual results of penetrating keratoplasty in patients with keratoconus of different stages. Glaz. 1998;(3). (In Russ.)
  5. Izmaylova SB. Medical-technology scheme of surgical treatment for different types of progressive keratectasia [dissertation]. Мoscow; 2014. 314 p. (In Russ.)
  6. Al-Suhaibani AH, Al-Rajhi AA, Al-Motowa S, Wagoner MD. Inverse relationship between age and severity and sequelae of acute corneal hydrops associated with keratoconus. Br J Ophthalmol. 2007;91(7):984-985. doi: 10.1136/bjo.2005.085878.
  7. Brian S, Boxer Wachler. Corneal collagen crosslinking with riboflavin. Cataract Refract Surg Today. 2005;(1):73-74.
  8. Ertan A, Muftuoglu O. Keratoconus clinical findings according to different age and gender groups. Cornea. 2008;27(10):1109-1113. doi: 10.1097/ICO.0b013e31817f815a.
  9. Leoni-Mesplie S, Mortemousque B, Touboul D, et al. Scalability and severity of keratoconus in children. Am J Ophthalmol. 2012;154(1):56-62. doi: 10.1016/j.ajo.2012.01.025.
  10. Mukhtar S, Ambati BC. Pediatric keratoconus: a review of the literature. Int Ophthalmol. 2018;38(5):2257-2266. doi: 10.1007/s10792-017-0699-8.
  11. Sabti S, Tappeiner C, Frueh BE. Corneal cross-linking in a 4-year-old child with keratoconus and Down syndrome. Cornea. 2015;34(9):1157-1160. doi: 10.1097/ICO.0000000000000491.
  12. Arora R, Gupta D, Goyal JL. Results of corneal collagen cross-linking in pediatric patients. J Refract Surg. 2012;28:759-762. doi: 10.3928/1081597X-20121011-02.
  13. Bakshi E, Barkana Y, Goldich Y. Corneal cross-linking for progressive keratoconus in children: our experience. Int J Keratoco Ectatic Corneal Dis. 2012;1:53-56.
  14. Buzzonetti L, Petrocelli G. Transepithelial corneal cross-linking in pediatric patients: early results. J Refract Surg. 2012;28(11):763-767. doi: 10.3928/1081597X-20121011-03.
  15. Soeters N, van der Lelij A, van der Valk R. Corneal crosslinking for progressive keratoconus in four children. J Pediatr Ophthalmol Strabismus. 2011;48:e26-29. doi: 10.3928/01913913-20110614-02.
  16. Bikbov MM, Zainutdinova GH, Usubov EL, et al. Results of keratectasia treatment by CXL in children and adolescents. Ophthalmokhirurgiya. 2015;(5):43. (In Russ.)
  17. Bikbov MM, Surkova VK. Corneal collagen crosslinking for keratoconus. A review. Ophthalmology in Russia. 2014;11(3):13-19. (In Russ.)
  18. Markova EY, Kostenev SV, Grigor’eva AG, Perfileva EA. Modern trends in the treatment of keratokonus in children. Ophthalmology in Russia. 2017;14(3):188-194. (In Russ.)
  19. Mirsaitova DR, Titov AV. Analyses of first results of intrastromal corneal segments implantation with phemtosecond maintenance in patients with keratoconus. Modern technologies in ophthalmology. 2019;3:140-143. (In Russ.)
  20. Caporossi A, Mazzotta C, Baiocchi S. Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients. Cornea. 2012;31(3):227-231. doi: 10.1097/ico.0b013e31822159f6.
  21. Chatzis N, Hafezi F. Progression of keratoconus and efficacy of pediatric [corrected] corneal collagen cross-linking in children and adolescents. J Refract Surg. 2012;28(11):753-758. doi: 10.3928/1081597X-20121011-01.
  22. Magli A, Forte R, Tortori A, et al. Epithelium-off corneal collagen cross-linking versus transepithelial cross-linking for pediatric keratoconus. Cornea. 2013;32(5):597-601. doi: 10.1097/ICO.0b013e31826cf32d.
  23. Mazotta C, Traversi C, Baiocchi S, et al. Corneal collagen cross-linking with riboflavin and ultraviolet a light for pediatric keratoconus: ten-year results. Cornea. 2018;37(5):560-566. doi: 10.1097/ICO.0000000000001505.
  24. Mc Anena L, Doyle F, O’Keefe M. Cross-linking in children with keratoconus: a systematic review and meta-analysis. Acta Ophthalmol. 2017;95(3):229-239. doi: 10.1111/aos.13224.
  25. Radner W, Zehemayer M, Skorpik C. Altered organization of collagen in apex of keratoconus corneas. Ophthalmic Res. 1998;30(5):327-332. doi: 10.1159/000055492.
  26. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5):620-627. doi: 10.1016/s0002-9394(02)02220-1.
  27. Perez-Straziota C, Gaster RN, Rabinowitz YS. Corneal cross-linking for pediatric keratcoconus: review. Cornea. 2018;37(6):802-809. doi: 10.1097/ICO.0000000000001579.
  28. Zotta PG, Diakonis VF, Kymionis GD, et al. Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients.
  29. J AAPOS. 2017;21(5):397-401. doi: 10.1016/j.jaapos.2017.07.205.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2020 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86503 от 11.12.2023 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80630 от 15.03.2021 г
.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies