THE EVALUATION OF THE STATE OF CHOROID IN THE PATIENTS PRESENTING WITH UVEITIS OF DIFFERENT ETIOLOGY BASED ON THE RESULTS OF OPTICAL COHERENCE TOMOGRAPHY



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The evaluation of the state of choroid in the patients presenting with uveitis is one of the promising directions in modern ophthalmological diagnostics because it provides the opportunity for obtaining the objective quantitative characteristics of the activity of the inflammatory process and thereby makes it possible to more accurately estimate the effectiveness of the treatment. It has been shown that the thickness of choroid considerably increases during the acute phase of Vogt-Koyanangi-Harada disease, active uveitis associated with Behcet’s disease, sarcoidosis, and toxoplasmosis and returns to the normal value under the influence of the treatment. In certain cases, the thickness of choroid decreases in comparison with that in the healthy eyes. The thinning of choroid was documented also at the stage of the clinical remission of birdshot retinochoroidopathy, Fuchs syndrome-associated uveitis, posterior non-infectious and idiopathic pan-uveites. It can possibly be the result of the atrophy of choroid due to the inflammatory and ischemic processes. Unfortunately, the available literature data have been obtained in disconnected studies of the choroid of the patients suffering from uveitis that involved only the small number of the patients and were confined to a few selected etiological and pathogenetic structural variants of this condition.

Full Text

Restricted Access

About the authors

L. A Katargina

The Helmholtz Moscow Research Institute of Eye Diseases, Russian Ministry of health

Moscow, 105062, Russian Federation

E. V Denisova

The Helmholtz Moscow Research Institute of Eye Diseases, Russian Ministry of health

Moscow, 105062, Russian Federation

O. V Novikova

The Helmholtz Moscow Research Institute of Eye Diseases, Russian Ministry of health

Email: olganovv@mail.ru
Moscow, 105062, Russian Federation

References

  1. Singh R., Invernizzi A., Agarwal A., Kumari N., Gupta A. Enhanced depth imaging spectral domain optical coherence tomography versus ultrasonography B-Scan for measuring retinochoroidal thickness in normal eyes. Retina. 2015; 35 (2): 250-6.
  2. Baltmr A., Lightman S., Tomkins-Netzer O. Examining the choroid in ocular inflammation: a focus on enhanced depth imaging. J. Ophthalmol. 2014; 2014: 459 136.
  3. Géhl Z., Kulcsár K., Kiss H.J. Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis. BMC Ophthalmol. 2014; 14: 103. doi: 10.1186/1471-2415-14-103.
  4. Regatieri C. V., Branchini L., Fujimoto J. G., Duker J. S. Choroidal imaging using spectral domain optical coherence tomography. Retina. 2012; 32: 865-76.
  5. Hogan M.J., Alvarado J.A., Weddell J.E., Histology of the Human Eye, Philadelphia: Saunders; 1971.
  6. Herrera L., Perez-Navarro I., Sanchez-Cano A., Perez-Garcia D., Remon L., Almenara C. et al. Choroidal thickness and volume in a healthy pediatric population and its relationship with age, axial length, ametropia, and sex. Retina. 2015; 35: 2574-83.
  7. Bidaut-Garnier M., Schwartz C., Puyraveau M., Montard M., Delbosc B., Saleh M. Choroidal thickness measurement in children using optical coherence tomography. Retina. 2014; 34: 768-74.
  8. Fujiwara T., Imamura Y., Margolis R., Slakter J.S., Spaide R.F. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am. J. Ophthalmol. 2009; 148 (3): 445-50.
  9. Read S.A., Collins M.J., Vincent S.J., Alonso-Caneiro D. Choroidal thickness in childhood. Invest. Ophthalmol. Vis. Sci. 2013; 54 (5): 3586-93.
  10. Park K.A., Oh S.Y., Choroidal thickness in healthy children. Retina. 2013; 33: 1971-6.
  11. Kardes E., Betül Ilkay Sezgin Akçay, Unlu C., Ergin A. Сhoroidal thickness in eyes with Fuchs uveitis syndrome. Ocul. Immunol. Inflamm. 2016; 14: 1-8.
  12. Cerquaglia A., Iaccheri B., Fiore T., Lupidi M., Torroni G., Fruttini D. et al. Full-thickness choroidal thinning as a feature of Fuchs uveitis syndrome: quantitative evaluation of the choroid by enhanced depth imaging optical coherence tomography in a cohort of consecutive patients. Graefe’s Arch. Clin. Exp. Ophthalmol. 2016; 254 (10): 2025-31.
  13. Maruko I., Iida T., Sugano Y., Oyamada H., Sekiryu T., Fujiwara T. et al. Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011; 31 (3): 510-7.
  14. Nakayama M., Keino H., Okada A.A. et al. Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. Retina. 2012; 32 (10): 2061-9.
  15. Fong A.H.C., Li K.K.W., Wong D. Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina. 2011; 31 (3): 502-9.
  16. Takahashi H., Takase H., Ishizuka A. et al. Choroidal thickness in convalescent Vogt-Koyanagi-Harada disease. Retina. 2014; 34 (4): 775-80.
  17. Da Silva F.T., Sakata V.M., Nakashima A. et al. Enhanced depth imaging optical coherence tomography in long-standing Vogt-Koyanagi-Harada disease. Br. J. Ophthalmol. 2013; 97 (1): 70-4.
  18. Hirooka K., Saito W., Namba K., Mizuuchi K., Iwata D., Hashimoto Y. et al. Significant role of the choroidal outer layer during recovery from choroidal thickening in Vogt-Koyanagi-Harada disease patients treated with systemic corticosteroids. BMC Ophthalmol. 2015; 15: 181.
  19. Nakai K., Gomi F., Ikuno Y., Yasuno Y., Nouchi T., Ohguro N. et al. Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography. Graefe’s Arch. Clin. Exp. Ophthalmol. 2012; 250 (7): 1089-95.
  20. Nazari H., Rao N.A. Resolution of subretinal fluid with systemic corticosteroid treatment in acute Vogt-Koyanagi-Harada disease. Br. J. Ophthalmol. 2012; 96 (11): 1410-4.
  21. Kim M., Kim H., Kwon H.J., Kim S.S., Koh H.J., Lee S.C. Choroidal thickness in Behcet’s uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Invest. Ophthalmol. Vis. Sci. 2013; 54 (9): 6033-9.
  22. Charteris D.G., Barton K., McCartney A.C.E., Lightman S.L. CD4+ lymphocyte involvement in ocular Behcet’s disease. Autoimmunity. 1992; 12 (3): 201-6.
  23. Ishikawa S., Taguchi M., Muraoka T., Sakurai Y., Kanda T., Takeuchi M. Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet’s disease. Br. J. Ophthalmol. 2014; 98 (11): 1508-13.
  24. Coskun E., Gurler B., Pehlivan Y., Kisacik B., Okumus S., Yayuspayi R. et al. Enhanced depth imaging optical coherence tomography findings in Behcet disease. Ocul. Immunol. Inflamm. 2013; 21 (6): 440-5.
  25. Mehta H., Sim D.A., Keane P.A., Zarranz-Ventura J., Gallagher K., Egan C.A. et al. Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis. Eye (Lond.). 2015; 29 (8): 1060-8.
  26. Güngör S.G., Akkoyun I., Reyhan N.H., Yeşilırmak N., Yılma-z G. Choroidal thickness in ocular sarcoidosis during quiescent phase using enhanced depth imaging optical coherence tomography. Ocul. Immunol. Inflamm. 2014; 22 (4): 287-93.
  27. Keane P.A., Allie M., Turner S.J. et al. Characterization of birdshot chorioretinopathy using extramacular enhanced depth optical coherence tomography. J.A.M.A. Ophthalmol. 2013; 131 (3): 341-50.
  28. Young M., Fallah N., Forooghian F. Choroidal degeneration in birdshot chorioretinopathy. Retina. 2015; 35 (4): 798-802.
  29. Vance S.K., Khan S., Klancnik J.M., Freund K.B. Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina. 2011; 31 (4): 717-23.
  30. Karampelas M., Sim D.A., Keane P.A. et al. Choroidal assessment in idiopathic panuveitis using optical coherence tomography. Graefe’s Arch. Clin. Exp. Ophthalmol. 2013; 251 (8): 2029-36.
  31. Bittencourt M.G., Kherani S., Ferraz D.A., Ansari M., Nasir H., Sepah Y.J. et al. Variation of choroidal thickness and vessel diameter in patients with posterior non-infectious uveitis. J. Ophthal. Inflamm. Infect. 2014; 4: 14.
  32. Goldenberg D., Goldstein M., Loewenstein A., Habot-Wilner Z. Vitreal, retinal, and choroidal findings in active and scarred toxoplasmosis lesions: a prospective study by spectral domain optical coherence tomography. Graefe’s Arch. Clin. Exp. Ophthalmol. 2013; 251 (8): 2037-45.

Copyright (c) 2017 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies