Microstructural changes in the retina in children with retinopathy of prematurity according to optical coherence tomography. Literature review

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Retinopathy of prematurity (ROP) is a crucial problem in modern ophthalmology. ROP is a vasoproliferative disease of the eyes in premature infants. Approximately 50,000 children worldwide have become blind because of ROP. The determining indicator in the development of visual acuity is the morphofunctional state of the macula, structural changes of which can lead to disturbances in its functions and, consequently, decreased vision.

The present review analyzed available OCT (optical coherence tomography) data on the morphometric and structural state of the retina in children with ROP. Morphometric features of the macular zone in children in the scar period of ROP can be presented by an increase in retinal thickness in the center of the fovea and changes in the profile of the macula by smoothness or absence of foveal depression. These are more pronounced in children after laser coagulation of the retina in the active phase of ROP and in very premature babies. In some cases with increased retinal thickness in the center of the fovea, the presence of internal layers and an increase in the thickness of the outer nuclear layer are noted. Structural features of the macula with favorable outcomes of RP can be expressed by traction displacement of the foveola, photoreceptor layer thinning and pigment epithelium unevenness, intra and epiretinal fibrosis, choriocapillaris layer atrophy, discontinuity of the connection of the outer and internal segments of the photoreceptors and the pigment epithelium–choriocapillaris complex, and central retinoschisis. Furthermore, this review presents mixed results from studies on the impact of structural changes in the macula in cicatricial ROP on visual function.

Full Text

Restricted Access

About the authors

Yuliya S. Khlopkova

Altai State Medical University

Author for correspondence.
Email: yulyahlopkova95@mail.ru
ORCID iD: 0000-0002-7615-2057
SPIN-code: 6919-0545

MD, researcher

Russian Federation, 40, avenue Lenina., 656038 Barnaul

Lyudmila V. Kogoleva

Helmholtz National Medical Research Center of Eye Diseases

Email: kogoleva@mail.ru

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

Vladimir I. Lebedev

Altai State Medical University

Email: sibvil@bk.ru
ORCID iD: 0000-0003-4840-3135

MD, Cand. Sci. (Med.)

Russian Federation, 40, avenue Lenina., 656038 Barnaul

References

  1. Blencowe H, Lawn JE, Vazquez T, et al. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatr Res. 2013;74(1):35–49. doi: 10.1038/pr.2013.205
  2. Isenberg SJ. Macular development in the premature infant. Am J Ophthalmol. 1986; 101(1):74–80. doi: 10.1016/0002-9394(86)90467-8
  3. Soong GP, Shapiro M, Seiple W, Szlyk JP. Macular structure and vision of patients with macular heterotopia secondary to retinopathy of prematurity. Retina. 2008;28(8):1111–1116. doi: 10.1097/IAE.0b013e3181744136
  4. van Driel D, Provis JM, Billson FA. Early differentiation of ganglion, amacrine, bipolar, and Muller cells in the developing fovea of human retina. J Comp Neurol. 1990;291(2):203–219. doi: 10.1002/cne.902910205
  5. Penfold PL, Provis JM, Madigan MC, et al. Angiogenesis in normal human retinal development: the involvement of astrocytes and macrophages. Graefes Arch Clin Exp Ophthalmol. 1990;228(3):255–263. doi: 10.1007/BF00920031
  6. Mintz-Hittner HA, Knight-Nanan DM, Satriano DR, Kretzer FL. A small foveal avascular zone may be an historic mark of prematurity. Ophthalmology. 1999;106(7):1409–1413. doi: 10.1016/S0161-6420(99)00732-0
  7. Katargina LA, Kogoleva LV. Pathogenesis of visual impairment in children with ROP. In: Avetisov SJe, Kashhenko TP, Shamshinova AM, editors. Visual functions and their correction in children: a guide for doctors. Moscow: Medicina; 2005. P. 459–475. (In Russ.)
  8. Katargina LA, Kogoleva LV. Selected lectures on pediatric ophthalmology. Neroeva VV, editor. Moscow: GeOTAR-Media; 2009. P. 27–61. (In Russ.) EDN: QLTALH
  9. Hammer DX, Iftimia NV, Ferguson RD, et al. Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study. Inves tOphthalmol VisSci. 2008;49(5):2061–2070. doi: 10.1167/iovs.07-1228
  10. Rudnik AYu, Somov EE. Macular changes in the late period after surgical treatment in children with early stages of the active period of retinopathy of prematurity. Russian pediatric ophthalmology. 2009;3:22–24. (In Russ.)
  11. Matta N, Young D, Boulton R. Mactier H. Survival of extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2010;95(2):F151–F152. doi: 10.1136/adc.2009.174417
  12. Sull AC, Vuong LN, Price LL, et al. Comparison of spectral/ Fourier domain optical coherence tomography instruments for assessment of normal macular thickness. Retina. 2010;30(2):235–245. doi: 10.1097/IAE.0b013e3181bd2c3b
  13. Lambrozo B, Rispoli M. Retinal OCT. Method of analysis and interpretation. Neroeva VV, Zajcevoj OV, editors. Moscow: Aprel; 2012. 83 p. (In Russ.)
  14. Akerblom H, Larsson E, Eriksson U, Holmström G. Central macular thickness is correlated with gestational age at birth in prematurely born children. Br J Ophthalmol. 2011;95(6):799–803. doi: 10.1136/bjo.2010.184747
  15. Wang J, Spencer R, Leffler JN, Birch EE. Critical period for foveal fine structure in children with regressed retinopathy of prematurity. Retina. 2012;32(2):330–339. doi: 10.1097/IAE.0b013e318219e685
  16. Yanni SE, Wang J, Chan M, et al. Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol. 2012;96(7):961–966. doi: 10.1136/bjophthalmol-2012-301612
  17. Park KA, Oh SY. Analysis of spectral-domain optical coherence tomography in preterm children: retinal layer thickness and choroidal thickness profiles. Invest Ophthalmol Vis Sci. 2012;53(11):7201–7207. doi: 10.1167/iovs.12-10599
  18. Wu WC, Lin RI, Shih CP, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity. Ophthalmology. 2012;119(9):1907–1916. doi: 10.1016/j.ophtha.2012.02.040
  19. Kogoleva LV. Clinical and functional state of the eyes in very premature children in the long term. Russian pediatric ophthalmology. 2014;9(3):14–19. (In Russ.) EDN: SNWTGL
  20. Kogoleva LV, Katargina LA, Sudovskaja TV, et al. Results of long-term follow-up of extremely preterm infants with retinopathy. Bulletin of Ophthalmology. 2020;136(5):39–45. (In Russ.) doi: 10.17116/oftalma202013605139
  21. Katargina LA, Rudnickaja JaL, Kogoleva LV, Rjabcev DI. Macular formation in children with retinopathy of prematurity according to optical coherence tomography. Russian ophthalmological journal. 2011;4(4):30–33. (In Russ.) EDN: QCLLCH
  22. Gerasimenko EV. The cicatricial period of retinopathy of prematurity: the state of the macular zone according to optical coherence tomography. Russian pediatric ophthalmology.2016;1:9–14. (In Russ.) EDN: VXEJGL
  23. Fulton AB, Hansen RM. Electroretinogram responses and refractive errors in patients with a history of retinopathy prematurity. Doc Ophthalmol. 1996;91(2):87–100. doi: 10.1007/BF01203688
  24. Fulton AB, Hansen RM, Petersen RA, Vanderveen DK. The rod photoreceptors in retinopathy of prematurity: an electroretinographic study. Arch Ophthalmol. 2001;119(4):499–505. doi: 10.1001/archopht.119.4.499
  25. Katargina LA, Rudnickaja JaL, Kogoleva LV. Influence of correction of refractive errors in the sensitive period on the morphofunctional development of the macula in children with retinopathy of prematurity. Russian ophthalmological journal. 2013;6(1):8–13. (In Russ.) EDN: QCLNPH
  26. Kogoleva LV, Katargina LA, Rudnitskaya YaL. Structural and functional state of the macula in retinopathy of prematurity. Bulletin of Ophthalmology. 2011;127(6):25–29. (In Russ.) EDN: ONOZRB
  27. Tereshhenkova MS, Erohina EV. Features of the central and peripheral parts of the retina in patients with cicatricial stages of retinopathy of prematurity according to spectral optical coherence tomography. Modern technologies in ophthalmology. 2020;4(35):229–230. (In Russ.) doi: 10.25276/2312-4911-2020-4-229-230
  28. Astasheva IB, Sidorenko EI, Aksenova II. Laser coagulation in the treatment of various forms of retinopathy of prematurity. Bulletin of Ophthalmology.2005;(2):31–34. (In Russ.) EDN: UGYXDX
  29. Katargina LA, Kogoleva LV. Recommendations for the organization of early detection and preventive treatment of active ROP. Russian ophthalmological journal. 2008;(3):43–48. (In Russ.)
  30. Katargina LA, Kogoleva LV, Denisova EV. Current trends in the treatment of active ROP. ARS MEDICA. 2009;(9):158–161. (In Russ.)
  31. Tereshcheko AV, Trifanenkova IG, Sidorova YuA, Panamareva SV. Pattern laser coagulation of the retina in the treatment of posterior aggressive retinopathy of prematurity. Bulletin of Ophthalmology. 2010;(6):38–43. EDN: NCEGXL
  32. Katargina LA. Retinopathy of prematurity, the current state of the problem and the tasks of organizing ophthalmological care for premature babies in the Russian Federation. Russian pediatric ophthalmology. 2012;(1);5–7. (In Russ.) EDN: PUJLAT
  33. Lebedev VI, Shamanskaja NN, Miller JuV. Organization of laser ophthalmic care for premature infants with retinopathy of prematurity in the neonatal department. Russian pediatric ophthalmology. 2014;9(4):31. (In Russ.) EDN: IHTTOF
  34. Sajdasheva JeI. Laser treatment of retinopathy of prematurity. Russian pediatric ophthalmology. 2014;9(4):47. (In Russ.)
  35. Shevernaja OA, Pasternak AJu, Nabokov AJu. The results of various methods of retinal coagulation in severe forms of retinopathy of prematurity. Russian pediatric ophthalmology. 2014;9(4):61. (In Russ.)
  36. Chen YH, Lien R, Chiang MF, et al. Outer retinal structural alternation and segmentation errors in optical coherence tomography imaging in patients with a history of retinopathy of prematurity. Am J Ophthalmol. 2016;166:169–180. doi: 10.1016/j.ajo.2016.03.030
  37. Krumova S, Voynikova D, Koleva-Georgieva D, et al. Macular Morphology in patients with retinopathy of prematurity. Open J Ophthalmol. 2020;10(1):59–68. doi: 10.4236/ojoph.2020.101008
  38. Pshenichnov MV, Kolenko OV, Mazurina OV. Morphological features of the structure of the macular area in children after laser coagulation of the retina for threshold stages of retinopathy of prematurity. Modern technologies in ophthalmology. 2018;2:128–130. (In Russ.) EDN: XSEPWX
  39. Recchia FM, Recchia CC. Foveal dysplasia evident by optical coherence tomography in patients with a history of retinopathy of prematurity. Retina. 2007;27(9):1221–1226. doi: 10.1097/IAE.0b013e318068de2e
  40. Villegas VM, Capó H, Cavuoto K, et al. Foveal structure–function correlation in children with history of retinopathy of prematurity. Am J Ophthalmol. 2014; 158(3):508–512. doi: 10.1016/j.ajo.2014.05.017
  41. Pueyo V, González I, Altemir I, et al. Microstructural Changes in the Retina Related to Prematurity. Am J Ophthalmol. 2015;159(4):797–802. doi: 10.1016/j.ajo.2014.12.015
  42. Wang J, Spencer R, Leffler JN, Birch EE. Characteristics of peripapillary retinal nerve fiber layer in preterm children. Am J Ophthalmol. 2012;153(5):850–855. doi: 10.1016/j.ajo.2011.10.028
  43. Park KA, Oh SY. Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity. Eye. 2015;29(12):1594–602. doi: 10.1038/eye.2015.166

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86503 от 11.12.2023 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80630 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies