Russian Pediatric Ophthalmology

Peer-review quarterly academic medical journal. 

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About

The journal founded in 2006 is intended for ophtalmologists, healthcare professionals, drug developers and regulators, researchers of scientific, medical and educational organizations

The aim of the journal is to provide pediatric ophthalmologists with data on pediatric ophthalmology issues, to enable exchange of experience in diagnosing and treating ocular diseases in children, to facilitate discussion of research results, and to improve pediatric eye care.

The reader will find on the pages of the journal reviews, lectures and original articles that have priority and deserve to be published in the professional medical journal.

APC, Publication & Distribution

  • Quarterly issues (4 times a year)
  • Continuoulsly publications online (Online First)
  • Hybrid Access (Open Access articles published with CC BY-NC-ND 4.0 License)
  • articles in English & Russian

 

Articles types

  • reviews
  • systematic reviews and metaanalyses
  • original research articles
  • clinical case reports and series
  • letters to the editor
  • short communications
  • clinial practice guidelines

Indexation

  • Russian Science Citation Index (eLibrary.ru)
  • CrossRef
  • Google Scholar
  • Ulrich’s International Periodicals Directory
  • WorldCat

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Current Issue

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Vol 17, No 1 (2022)

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Original study article

Characteristics of antibody production to individual cytomegalovirus proteins in children with keratitis and uveitis
Krichevskaya G.I., Katargina L.A., Alatortseva G.I., Dotsenko V.V., Nesterenko L.N.
Abstract

The clinical diagnosis of cytomegalovirus (CMV) eye pathology in children needs laboratory confirmation. The disadvantages of determining antibodies to CMV in serum in enzyme-linked immunosorbent assay (ELISA) include the presence of false positive and false negative results.

AIM: To determine the features of the synthesis of antibodies to the proteins of the tegument pp65, pp150, pp28 and the DNA-binding protein pp52 of cytomegalovirus, as well as to compare the diagnostic effectiveness of two laboratory methods of serodiagnostics of CMVI in children with uveitis and keratitis of different genesis: enzyme immunoassay and linear immunolysis.

MATERIAL AND METHODS: A total of 30 children (age 5–16 years) with uveitis (n=14) and keratitis (n=16) were included in the study. The IgM and IgG antibodies to the immediate early (IE) and late antigens of the virus (serological markers of primary, chronic, and reactivation of chronic infection) were determined in the ELISA. The IgG antibodies to individual recombinant CMV antigens containing only immunodominant protein fragments of viral antigens were studied in the line immunoassay (LIA): the main nonstructural IE protein, DNA-binding phosphoprotein p52, and phosphoproteins of the tegument p150, p65, and p28. The results of LIA were evaluated visually.

RESULTS: CMV infection (CMVI) in children with uveitis in ELISA was almost 2 times higher than that with keratitis (10/14%–71% vs. 6/16%–37.5%, p >0.05). Of the four positive results for detection of antibodies to IE antigen in ELISA, one was confirmed in LIA. In general, the discrepancy between the results of the determination of IgG antibodies to IE antigen in ELISA and LIA was noted in 13% of serum samples. LIA showed the increased frequency (p >0.05) and intensity (p <0.05) of antibody formation to viral antigens p65 and p52 in uveitis compared with keratitis, which confirmed the important role of CMVI in the pathogenesis of uveitis.

CONCLUSION: Both methods revealed a higher level of CMVI in children with uveitis than those with keratitis. IgG antibodies to IE-antigen serological markers of the reactivation of chronic CMVI have clinical importance because they serve as the basis for the appointment of antiviral therapy. Discrepancies between the results of ELISA and LIA in the detection of antibodies to IE antigen indicate the expediency of confirming the results of ELISA in LIA.

Thus, laboratory examination of sera in ELISA with subsequent analysis of antibodies to individual recombinant CMV antigens in LIA is an effective, highly sensitive, and highly specific method to verify CMVI and determine its activity. The most informative action is the determination of IgG antibodies to recombinant CMV antigens: IE antigens, p65, and p52.

Russian Pediatric Ophthalmology. 2022;17(1):5-11
pages 5-11 views
Role of visual illusions in the assessment of digital color images of aggressive posterior retinopathy of premature
Fomina N.V., Saidasheva E.I., Boiko E.V., Goravskaya E.G.
Abstract

AIM: To estimate the role of visual illusions in the diagnosis of aggressive posterior retinopathy of prematurity (APROP) using a pediatric retinal camera.

MATERIAL AND METHODS: A retrospective analysis of images of the fundus structures obtained using a pediatric retinal camera was carried out in 31 children diagnosed with APROP. The children were treated at St. Petersburg’s Children’s Hospital N17 of St. Nicholas from January 2011 to December 2018. Based on the analysis of digital colored images of the fundus, the diagnosis of ARN was confirmed in 18 children (58%), and in the remaining 42% of cases (13 children), the diagnosis was revised from APROP to classic ROP (stage 3, with signs of “plus” disease, zones I or II). Preterm infants with classic ROP were excluded from the study group.

RESULTS: A total of 14 out of 18 (78%) children with APROP were initially diagnosed with manifestations of classical ROP. Analysis of colored images obtained with a retinal camera showed that all of them manifested Mach’s bands, which created the effect of a demarcation line or a demarcation ridge at the border of light and dark areas. Although they were manifestations of APROP, these illusions were the reason for the diagnosis of classical ROP along with the designation of stages. The effect of Mach band illusion was neutralized by the study of colored photographs on the monitor screen under high magnification.

CONCLUSION: Visual illusions create difficulties in the timely diagnosis of APROP during the investigation with a retinal camera. They may influence the treatment of patients and lead to poor outcomes of this most severe form of ROP, including the development of retinal detachment and visual impairment in children.

Russian Pediatric Ophthalmology. 2022;17(1):13-18
pages 13-18 views

Clinical recommendations

Possible causes of the ineffectiveness of sinustrabeculectomy in children with congenital glaucoma
Arestova N.N., Panova A.Y., Pleskova A.V., Sorokin A.A.
Abstract

AIM: On the basis of studying the causes of errors in finding the trabecular zone to be excised during trabeculectomy in children with congenital glaucoma, this study presents a proven and effective method for simple intraoperative localization of the trabecular area.

MATERIAL AND METHODS: The analyses of many years of experience in the examination and treatment of children with congenital glaucoma at the Department of Eye Pathology in Children of Helmholtz National Medical Research Center (100–200 children annually) revealed the anatomical and morphological features of the eyes of children with congenital glaucoma and the reasons for the insufficient effectiveness of trabeculectomy.

RESULTS: A retrospective gonioscopic analysis of the condition of the operation area and internal fistula after trabeculectomy in children with congenital glaucoma showed that erroneous choice of the area of the trabecular region to be excised during surgery is one of the reasons for the inefficiency of trabeculectomy, and it results from the incorrect determination of the projection location of the apex of anterior chamber angle (ACA) onto the sclera caused by the significantly distorted anatomical parameters of the child’s eye due to the softness and extensibility of the limbus and sclera. On the stretched eyes of children with congenital glaucoma, especially those with buphthalmos and cloudy cornea, accurate determination of the boundaries of the altered cornea, limbus, and projection of the ACA’s apex onto the sclera is visually impossible.

CONCLUSION: During trabeculectomy of the eyes of children with congenital glaucoma, for the accurate localized projection of the apex of the ACA’s onto the sclera and the trabecular zone to be excised, a simple and accessible method of clarifying diaphanoscopy intraoperatively must be used to correctly select the trabeculectomy zone, especially on stretched eyes.

Russian Pediatric Ophthalmology. 2022;17(1):19-24
pages 19-24 views
Electronic video magnifiers as a low-vision aid for patients with Stargardt disease
Baibarin K.A., Katargina L.A.
Abstract

Electronic video magnifiers outperform optical systems in terms of convenience and image quality. However, visually impaired patients and ophthalmologists in Russian Federation mostly lack knowledge of these useful technical rehabilitation devises. As shown by a survey of patients (n=141) with inherited retinal dystrophy, conducted by the public organization “Look To See!” 13% of patients use video magnifiers for writing, and 25% are satisfied with their devices. This article compensates for the gap in knowledge about electronic video magnifiers.

Video magnifiers come in three main types: handheld, desktop, and portable. Wearable video magnifiers are the recent addition to these types. Each type has its own advantages and disadvantages, which determine their main functionality. Handheld video magnifiers are suitable for reading, desktop ones are used to equip a workplace; portable ones are ideal for schoolchildren because they can be used in reading and writing and easily carried to classes. Wearable video magnifiers are a promising class, but a well-established view on their use is still lacking.

Ophthalmologists must have not only knowledge about the technical component but also the mechanism of operation of video magnifiers and how to draw up the necessary documents for their acquisition after establishing a disability and for their legitimate use in a general education school.

Russian Pediatric Ophthalmology. 2022;17(1):25-31
pages 25-31 views
The new edition of the international classification of retinopathy of premature. Part 1
Saidasheva E.I.
Abstract

Retinopathy of prematurity (ROP) is still one of the main causes of blindness and low vision from early childhood in developed countries and therefore remains the focus of attention of researchers and clinicians. The International Classification of Retinopathy of Prematurity (ICROP) was initially adopted in 1984, expanded in 1987, amended in 2005, and revised in 2021. Part 1 of this article discusses the new edition of the ICROP3. The reasons for updating the ICROP3 and the composition of the International Committee, which was specially organized for this purpose, are indicated. The new and third edition retains the current definitions (zone, stage, and extent of the disease). The main updates in ICROP3 include the improved classification of indicators, two of which, in the author’s opinion, are most significant for the acute stages of the disease. The definition of posterior zone II region and the recognition that retinal vascular changes in ROP represent a continuous spectrum from normal to preplus- and plus disease, with images demonstrating this range. In conclusion, the new edition of the ICROP3 requires a deep reading and discussion between domestic experts and must be introduced to clinical practices and the educational process. The next article will continue the discussion on the remaining additions/updates to ICROP3.

Russian Pediatric Ophthalmology. 2022;17(1):33-37
pages 33-37 views

Case reports

A case of combination of dacryocystocele with a nasolacrymal cyst in infant child
Prisich N.V., Brzheskiy V.V., Verezgov V.A., Pavlov P.V., Efimova E.L., Sadovnikova N.N.
Abstract

INTRODUCTION: Dacryocystocele (hydrops of the lacrimal sac) is a rare variant of a congenital pathology caused by the obstruction of proximal and distal lacrimal ducts, followed by progressive distension of the lacrimal sac [1]. Given the accumulation of abundant contents in the lacrimal sac and nasolacrimal duct, the membrane that closes their outlet under the inferior turbinate can be stretched, and the prominence of such a membrane into the inferior nasal passage is in the form of the so-called nasolacrimal cyst [3].

Description of the clinical case. A 1.5-month-old girl was hospitalized in the ophthalmology department of the University. Below are the history data. At the 30th week of pregnancy, the fetus had a bilateral space-occupying lesion in the area of the inner canthus of the eye. At birth, the child had a dense swelling in the region of the left lacrimal sac but without discharge. From birth, he had difficulty in nasal breathing.

RESULTS: According to the results of multislice computed tomography of the lacrimal ducts with contrast (Ultravist), cavity formations were found under the inferior turbinate on both sides with a contrast level. At the age of two months, the child, accompanied by an otolaryngologist, underwent surgery for the removal of nasolacrimal cysts on both sides and reconstruction of the lacrimal ducts and their intubation with a silicone thread on the left. After surgical treatment, the outflow of tears and nasal breathing were restored, and no signs of dacryocystocele were detected. The silicone thread was removed after 1 month, and no tear production was observed.

DISCUSSION: Treatment of children with dacryocystocele involves the simultaneous reconstruction of lacrimal ducts by an ophthalmologist and excision of the nasolacrimal cyst by an otolaryngologist.

CONCLUSION: When examining a child with dacryocystocele, the possible presence of a nasolacrimal cyst should be considered. The interaction of an ophthalmologist and an otolaryngologist at all stages of the treatment and diagnostic process enables the prevention of disease complications and unnecessary surgical procedures.

Russian Pediatric Ophthalmology. 2022;17(1):39-45
pages 39-45 views

Information

Russian scientific and practical conference with international participation «Laser intraocular and refractive surgery». section «Pediatric ophthalmology»
Shefer K.K., Boiko E.V., Saidasheva E.I.
Abstract

The article is devoted to reviewing the problems that were discussed in the section «Pediatric ophthalmology», organized for the first time within the Russian scientific and practical conference with international participation in «Laser intraocular and refractive surgery». The conference was held on December 10–11, 2021 in St. Petersburg and organized by the St. Petersburg branch of S. Fyodorov «Eye Microsurgery» Federal State Institution with the support of the Society of Ophthalmologists of Russia and North-Western State Medical University named after I.I. Mechnikov. In the pediatric section, 11 reports were made by leading Russian and foreign experts, and the topics were mainly related to the use of laser technologies in ophthalmopediatric practice. The discussion focused on the issues of diagnosis and laser treatment of premature retinopathy and other retinal diseases, modern approaches and results of surgical and contact correction of ametropias (keratoconus, hypermetropia, and progressive myopia) in childhood, and clinical cases of the effectiveness of complex treatment of bilateral retinoblastoma. In conclusion, an overview of new portable technologies for visualization of the state of anterior and posterior eye parts was presented, which is especially important for pediatric ophthalmologists.

Russian Pediatric Ophthalmology. 2022;17(1):47-51
pages 47-51 views


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